Quinacrine dihydrochloridedna alkylation inhibitor. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves. Quinacrine definition of quinacrine by merriamwebster. Quinacrine dihydrochloride is the dihydrochloride salt of the 9aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine hci powder treatment ind sought by fda pink sheet.
However, if you notice yellow discoloration of your eyes, check with your doctor as soon as possible because medical attention may be required. In a preliminary report 1 we indicated that quinacrine hydrochloride atabrine has a definite place in the treatment of patients with lupus erythematosusespecially in those with the chronic discoid variety. Mepacrine hydrochloride drug bnf content published by nice. We assessed the accumulation of quinacrine in the brains, kidneys, livers and spleens of fvb6090 and mdr 00 6090 mice at 75 and 90 dpi by quantitative lcmsms and comparison to known standards fig. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factorkappab nfkappab, which may result in the induction of tumor suppressor p53 transcription, the restoration of p53dependent apoptotic pathways. Quinacrine alters cell membrane permeability and is clinically used to treat infections of giardia. Identification of the substancemixture and of the companyundertaking product name.
Recent research found that quinacrine can be used to treat breast cancer, 5455 colon cancer, 56 nonsmall cell lung cancer nsclc, 57 etc. It is used in cell biological experiments as an inhibitor of phospholipase a2. Cas 69056 quinacrine hydrochloride for synthesis, 98. Quinacrine is a dyelike medicine and commonly causes yellow discoloration of the skin and urine, and darkening of the fingernails and toenails. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factorkappab nfkappab, which may result in the induction of tumor suppressor p53 transcription, the restoration of p53dependent apoptotic. Chemical product and company information manufacturer name hospira, inc. Quinacrine dihydrochloride 69056 tci chemicals india pvt. Pdf followup of insertion of quinacrine hydrochloride. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factorkappab nfkappab, which may result in the induction of tumor suppressor p53 transcription, the restoration of p53dependent apoptotic pathways, and tumor cell apoptosis. Quinacrine dihydrochloride dihydrate is a pla2 phophoslipase a2 inhibitor. Symptoms of overdose include seizures, hypotension, cardiac. Quinacrine mustard dihydrochloride, cas 42450, is a high purity and quality chemical used as fluorescent probe for labeling chromosomal dna.
Msds hydrochloric acid d p j c o a t i n g s y s t e m s pty ltd abn 56 005 509 679 acn 005 509 679 victoria. Apparently the englishspeaking world first became aware of the value of quinacrine in. Material safety data sheet section 1 thioglycolic acid 1 chemical product and company identification msds name. Safety data sheet according to 29cfr19101200 and ghs rev. M, blocks voltagedependent sodium channels ic 50 3. Continuous quinacrine treatment results in the formation of. Q2035 69056 c 23 h 30 cln 3 o2hcl spectrum chemical. The information in cameo chemicals comes from a variety of data sources. Quinacrine bulk powder side effects by likelihood and severity common side effects.
Quinacrine hydrochloride is the dihydrochloride salt of the 9aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Find msds or sds, coa, data sheet and other information of high quality specialty chemicals manufacturer, supplier, exporter. Quinacrine dihydrochloride 69056 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals. Quinacrine, aslo known as mepacrine, is a 9aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine dihydrochloride dihydrate cas 6150 abmole. Setanaxib gkt7831 new gkt7831 is a potent, dual nadph oxidase nox1nox4 inhibitor with ki of 110 nm and 140 nm, respectivelyl. Quinacrine, also commonly known as atebrine, is a compound which is commonly used as an antiprotozoal agent.
Quinacrine dihydrochloride dihydrate is an inhibitor of achr, cpla2, maoa and maob. Empirical formula hill notation c 23 h 30 cln 3 o 2hcl. Cb839telaglenastat new cb839 is a potent, selective, and orally bioavailable glutaminase inhibitor with ic50 of 24 nm for recombinant human gac. Atebrin dihydrochloride, mepacrine dihydrochloride. Quinacrine hydrochloride hydrate safety data sheet section 2. Quinacrine dihydrochloride is an inhibitor of cpla2, maoa and maob. Determination of quinacrine dihydrochloride dihydrate. Quinacrine dihydrochloride acts as an achr acetylcholine receptor antagonist. Sigmaaldrich offers a number of quinacrine dihydrochloride products. Hospira, formerly the hospital products division of abbott laboratories, was. Buy quinacrine dihydrochloride dihydrate from abmole bioscience. Pharmacokinetics of quinacrine after intrapleural instillation in rabbits and man. Material safety data sheet quinacrine hydrochloride dihydrate msds section 1. Quinacrine dihydrochloride mepacrine dihydrochloride is a fluorescent probe for the conformational transitions of the cholinergic receptor protein.
It appears to interfere with the parasites metabolism. Identification of the substancemixture and of the companyundertaking. Quinacrine dihydrochloride dihydrate c23h36cl3n3o3 pubchem. Important update all sales after march 2, 2020 are final and non. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factorkappab nfkappab, which may result in the induction of tumor suppressor p53 transcription. In colon cancer cells, quinacrine induces apoptosis, activates p53 and p21, and inhibits topoisomerase. And address 275 north field drive lake forest, illinois 60045 usa note.
Suppliers list, emailrfq form, molecular structure, weight, formula, iupac, synonyms for quinacrine hcl cas no. We wish now to report on our additional experience and longer observation of the patients treated. It is a yellow fluorescent dye also used in chromosome banding. Hydrochloric acid, 37% ww safety data sheet according to federal register vol. Quinacrine hydrochloride for synthesis205395 69056 c23h30cln3o. The mean excitation wavelength for quinacrine dihydrochloride is 440 nm and the mean emission wavelength is 510 nm wolbers, et al, 1990. Quinacrine, dihydrochloride c23h32cl3n3o cid 16760629 structure, chemical names, physical and chemical properties, classification, patents, literature. P4580 410 this document is only controlled while on the praxair, inc.
Quinacrine prevents misfolding of prion protein with an ec50 value of 0. Determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants article in journal of pharmaceutical sciences 1008. Quinacrine hcl is an antimalarial agent that was originally produced in the 1920s. It inhibits voltagedependent sodium channels with an ic50 value of 3. In addition to medical applications, mepacrine is an effective in vitro research tool for the epifluorescent visualization of cells.
Composition depends upon temperature and decrease in ph. Quinacrine dihydrochloride mepacrine dihydrochloride. Encouraged by the report of page, 1 we started the treatment of lupus erythematosus with quinacrine atabrine hydrochloride in january, 1952. It acts by inhibiting the inflammatory enzyme phospholipase a2, and by binding to giardia dna, blocking it from being read. Identification of the substancemixture and of the companyundertaking 1. Quinacrine hydrochloride cblc102 is an orally active dual secretory phospholipase a2 spla2 and nf. Quinacrine is an acridine compound with diverse biological activities that has also been used as a stain for dna and rna in fixed cells and for fluorescent tracking of acidic vesicles, such as lysosomes, in live cells. Quinacrine exhibits antiparasitic, antiprotozoan, anticancer, and antiinflammatory activities. Sn390, mepacrine dihydrochloride, quinacrine 2hcl quinacrine hydrochloride is the dihydrochloride salt of the 9aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. It shows synergistic inhibition of prostate cancer cells when used in combination with paclitaxel or lovastatin.
Mepacrine hydrochloride drug bnf content published by. Mepacrine is also used offlabel for the treatment of systemic lupus erythematosus, indicated in the treatment of discoid and subcutaneous lupus erythematosus, particularly in patients unable to take chloroquine derivatives. Quinacrine dihydrochloride mepacrine dihydrochloride shows activity in the low. Quinacrine hydrochloride 2product catalogue number. Page at the time of his report had treated 18 patients with lupus erythematosus, and only 1 failed to exhibit improvement. These side effects are only temporary and will go away when you stop taking this medicine. Quinacrine dihydrochloride is a nonspecific pla2 phospholipase a2 inhibitor. Determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants. Apr 25, 20 erlotinib hydrochloride and quinacrine dihydrochloride in stage iiibiv nonsmall cell lung cancer the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Where the neat test chemical is weighed and diluted, wear a nioshapproved half face respirator equipped with an organic vaporacid gas cartridge specific for organic vapors, hcl, acid gas and so2 with a dustmist filter.
Material may be irritating to the mucous membranes and upper respiratory tract. If experienced, these tend to have a less severe expression. Quinacrine dihydrochloride is a bright yellowish needles or bright yellow powder. Chemical product and company identification product name. B activation inhibitor originally launched by bayer over 80 years ago for the treatment of malaria. Production of the powder form of the drug, a sclerosing.
We have tried to make it as accurate and useful as possible, but can take no responsibility for its use, misuse, or accuracy. M and suppresses aldehyde oxidase with an ic50 value of 3. Quinacrine, also called mepacrine, is a medication in the same drug class as hydroxychloroquine and is used in the treatment of lupus as well. Also used in measurement of sequence specificity with taq dna polymerase. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. Quinacrine definition is an antimalarial drug derived from acridine and used especially in the form of its dihydrochloride c23h30cln3o2hcl2h2o.
Patients receive erlotinib hydrochloride orally podaily on days 128 and quinacrine dihydrochloride po thrice daily tid on days, 17 and po daily from days 828. Fda briefing document pharmacy compounding advisory committee. Quinacrine is an acridine derivative used to treat lupus and resistant giardiasis. The exact way in which quinacrine works is unknown. In addition, by binding to nucleoproteins, quinacrine suppress the lupus erythematous cell factor and acts as a strong inhibitor of cholinesterase. Material safety data sheet sodium hypochlorite unil. Quinacrine hydrochloride drug information, professional. Quinacrine hydrochloride hydrate safety data sheet supersedes revision. Quinacrine mustard dihydrochloride casnumber 42450. Erlotinib hydrochloride and quinacrine dihydrochloride in. Quinacrine, dihydrochloride cas 69056 scbt santa cruz. An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. Quinacrine for lupus carefirst specialty pharmacys blog. The hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents.
Sigmaaldrich material safety data sheet date printed. The dihydrochloride salt of the 9aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Request pdf determination of quinacrine dihydrochloride dihydrate stability and characterization of its degradants although quinacrine dihydrochloride dihydrate is a widely used drug substance. Material safety data sheet of quinacrine dihydrochloride. As an intrapleural sclerosing agent, it is used as pneumothorax prophylaxis in patients at high risk of recurrence, e. However, if you notice yellow discoloration of your eyes, check with your doctor as soon as possible because. Mepacrine is not the drug of choice because side effects are common, including toxic psychosis, and may cause permanent damage. The efficacy of three transcervical insertions of quinacrine hydrochloride pellets 1 month apart to produce tubal occlusion was evaluated in 151 women in valdivia, chile. This information was last updated on october 17, 2003. For research use only, not for human or veterinary use. Nov 26, 2009 quinacrine accumulation in treated, rmlinoculated fvb and mdr 00 mice. Quinacrine inhibits succinate oxidation and interferes with electron transport. Quinacrine may be injected into the space surrounding the lungs to prevent reoccurrence of pneumothorax. Quinacrine, dihydrochloride acts as an achr acetylcholine receptor antagonist.
Reevaluation of the mutagenic potential of quinacrine dihydrochloride dihydrate. Find patient medical information for quinacrine bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Quinacrine dihydrochloride 69056 q2035 spectrum chemical. Quinacrine dihydrochloride dissolves in hot water to produce a solution that is vividly fluorescent under ultraviolet light.
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